Effects of Nostoc commune on memory impairment in global cerebral ischemia

Background and Aim : Cerebral ischemia/reperfusion (I/R) injury is mediated by multiple mechanisms such as oxidative stress. Stroke patients exhibit cognitive and emotional changes. The extract of nostuc commune had high antioxidative activity.in this study is investigated effect of Nostoc commune on cognitive impairment indused by I/R in animal model.Methods : Male wistar rats weighing 200-300 g were used and divided into 5 groups. Animals in I/R group were randomly divided into 3 groups including IR, N35 (35mg/Kg Nostoc Commune), N70 (70mg/Kg Nostoc Commune) .The animals were gavaged for two weeks. than, the animals were anesthetized by intraperitoneal injection of ketamine and xylzine . After excluding the skin and muscles by identifying Common carotid arteries were dissected from the vagus nerve and carotid body, both the left and right carotid arteries were selected and closed for 5 minutes by vascular clamps. Then remove the clamps for 10 minutes to continue the blood flow. Again, we blocked the carotid arteries for 5 minutes. 48 hours after I/R induction, novel object test was determined in all groups.Results : The discrimination index were significantly decreased (P> 0.001) in I/R group compared with the control group. Pretreatment with Nostoc Commune (70 mg/kg) significantly reversed the decreased discrimination index (P<0.01) as compared with the I/R group.