Evaluation of methamphetamine-induced cognitive impairments using the novel object recognition task in rodents

Background and Aim : Methamphetamine (MA) is a widely abused synthetic psychostimulant that produces cognitive impairment in MA abusers. MA-induced cognitive impairment in rodents may be useful as animal models of cognitive deficits in MA abusers. We observed that novel object recognition task used in many articles that investigated cognitive deficits produced by MA in the animal. The novel object recognition task measure non-spatial memory in rodent and it s based on natural tendency animal to explore novel object. It has been reported that this task has a similarity with the recognition task that is used in human to evaluate declarative memory impairment.Methods : in this review, we summarized the results of almost all published these reports and their molecular mechanisms involved in memory impairment underlying use novel object recognition test in different administration of MA paradigm.Results : We find that main neurobiological mechanisms that participate in MA-induced recognition deficits are monoaminergic systems dysfunction. Our review revealed that this impairment observes in a different type of MA dosing regimen in the rodents.Conclusion : It considers that NOR is an appropriate task for neuroscientist in cognitive function fields, their neurobiological basis, and also for evaluating the efficacy of new therapeutic agents.

Keywords:

Methamphetamine , Novel object recognition test , Monoaminergic systems , cognitive impairment , Rodents