Effect of Vitamin D Supplementation on Vitamin D Levels of Term and Preterm Neonates and their Mothers: A Clinical Trial Study

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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JR_INJPM-7-11_001

تاریخ نمایه سازی: 17 دی 1398

Abstract:

  Background: Vitamin D deficiency is a worldwide issue and the effect of vitamin D supplementation alone as a possible option to prevent that is still under examination.Therefore, the aim of this study was to evaluate the effect of vitamin D supplementation on term and preterm neonates and mothers for 4 months. Materials and Methods In this clinical trial, 30 term neonates and 30 preterm neonates along with their mothers created a total of 120 participants who were referred to the maternity unit of Vali-e-Asr hospital in Birjand, Iran, in 2018. Neonates and mothers were supplemented with vitamin D supplementation of 400 IU/day and 50,000 IU/month of vitamin D drops and tablets, respectively. Serum vitamin D levels of mothers and infants were measured during delivery, birth and after 4 months using ELISA method. P Results: The level of vitamin D in term and preterm neonates was 24.53±10.93 and 41.30±12.87, 19.45±8.88 and 43.78±15.51 ng/ml at birth and at 4 months of age, respectively. There was a significant difference between the mean level of vitamin D at birth and 4 months later in both infants and mothers (P<0.001). There was also a significant positive correlation between vitamin D levels of mothers during labor and neonates at birth (P<0.001). Conclusion Although vitamin D deficiency was high, regular consumption of vitamin D supplements has a significant effect on vitamin D levels and could increase the level of vitamin D to the normal levels, particularly in neonates.

Authors

Bahareh Tanbakuchi

Resident of Pediatrics, Department of Pediatrics, Faculty of Medicine, Birjand University of Medical Sciences (BUMS), Birjand, South Khorasan Province, Iran.

Fatemeh Taheri

Professor, Atherosclerosis and Coronary Artery Research Center, Department of Pediatrics, Faculty of Medicine, Birjand University of Medical Sciences (BUMS), Birjand, South Khorasan Province, Iran.

Mahmoud Zardast

Associate Professor, Atherosclerosis and Coronary Artery Research Center, Department of Pathology, Faculty of Medicine, Birjand University of Medical Sciences (BUMS), Birjand, South Khorasan Province, Iran.

Abbasali Ramazani

Social Determinants of Health Resaerch Center, Department of Epidemiology and Biostatistics, Birjand University of Medical Sciences, Birjand , Iran.