CAV3 Variants among Iranian Patients with Cardiomyopathy

Introduction:Cardiomyopathy is one of the major defects of heart failure which causes heart disability to pump blood for metabolic activities. Some types of Cardiomyopathy are Hypertrophic (HCM), Restrictive (RCM) and Dilated (DCM), which DCM is the most common inherited type. Here we studied CAV3 gene variants as a sarcomeric gene; make an important role in demonstration of this disease.Materials & Methods: All entrants were selected from cardiomyopathy patients who have identified by Echocardiography results. Blood samples were collected and after conducting PCR, CAV3 was sequenced.Results: This study showed that variants of CAV3 gene play no significant role in demonstration of cardiomyopathy.Conclusion & discussion: The result didn’t show any specific variant on CAV3, but further studies on involved genes in cardiomyopathy are beneficial and necessary way of diagnosis and treatment

Keywords:

Cardiomyopathy , CAV3 , PCR