Effect of Ferula assa foetida on wound healing in full-thickness infected wounds with methicillin resistant Staphylococcus aureus

Objective: Wound healing is the interaction of complex events in cellular and biochemical actions ending up the reestablishment of structural and functional integrity of injured tissues. Methicillin-resistant Staphylococcus Aureus (MRSA) is the most widespread bacterial pathogen causing various infections ranging from skin and soft tissue infections to serious invasive infections, such as pneumonia, endocarditis, bacteremia and sepsis. Rising antibiotic resistance and diminishing investment by the pharmaceutical industry in the development of new antibiotics have created an urgent need for novel anti-MRSA agents. In this study the effect of Ferula assa foetida on wound healing in full-thickness infected wounds with methicillin resistant Staphylococcus aureus is going to be evaluated.Material and Methods: For excisional wound healing model eight male white Wistar rats were randomized into two groups of four rats each: Control group (CG) including creation of wounds, inoculation of MRSA and no treatment, FAF (Ferula assa foetida) group including creation of wounds, inoculation of MRSA and dressing with Ferula assa foetida extract. Wound size was measured on 6, 9, 12, 15, 18 and 21 days after surgery. Wound microbial counting was performed. For this purpose on days 2, 4 and 6 after wounding microbial samples were taken by the swab and cultured on blood agar and incubated for 24 h at 37 ° C, after which colonies were counted.Results: Microbiology and reduction in wound area indicated that there was significant difference (P < 0.05) between second group and first group.Discussion: It was concluded that the Ferula assa foetida had a reproducible wound healing potential and hereby justified its use in practice.

Keywords:

Ferula assa foetida , infectious wound , wound repair , rat