Hydrogels used in wound healing: Clinical trials (2010-2019)

Background: Tissue repair is process in which the growth factors leading to an integration of changes that involve cell proliferation and the production of the extracellular matrix. Hydrogels are three-dimensional networks that have 90–99% water capacity. This hydrophilic polymer chains can play important roles in drug delivery and facilitate efficient oxygen transfer. Furthermore, other properties of hydrogel biomaterials included in biocompatibility, high-sensitive to physiological environments, adjustable mechanical properties, sufficient elasticity and predictable degradation rates, make them great candidates for biomedical applications. Recently hydrogels have been developed for wound healing. Material and method: This summarized review article shows the hydrogel applications for wound healing.Result: According to do research, hydrogels play an importance role in wound healing and they have entered into clinical trial stages. Examples of available (partially) commercial wound dressings are the polyacrylamide/polysaccharide based FlexiGel® (Smith & Nephew), the poly(ethylene glycol) (PEG)/oakin based Oakin® (Amerigel), and the polyurethane (PU) based AquaClear® (Paul Hartmann AG) ) hydrogel wound dressings.Conclusion: It can be end that hydrogels are one of the great candidates for wound repair as dressing materials. More researches are needed to lead to low cost proprietary hydrogel dressings to help and increase wound healing.

Keywords:

wound healing , Hydrogel , Clinical trial