Vulvar cancer in Iran: retrospective study over 20 years (1998-2018)

Objectives: Our study is designed to evaluate the frequency, stage and outcome of patients with vulvar cancer.Methods: In this retrospective observational study we studied patients records with diagnosis of vulvar cancer who referred to department of gynecology oncology, Emam-Khomeini Hospital (EKH), Tehran, Iran, between January 1998 and December 2018. A total of 106 cases of vulvar cancers were found in the records of outpatient oncology clinic of medical university of Tehran university. Survival was estimated using the Kaplan-Meier analysis with SPSS version of 24.Results: The mean age of the 106 patients in the study was 59.2 years. The most site of tumor involvement was major labial (39.1%). Vulvar cancer significantly was more in multiparous (p<0.001) and menopause patients (p<0.001). Squamous Cell Carcinoma was the most pathology of vulvar cancer (72.2%).ninety patients (84.9%) had surgery as a primary treatment, (53.3%) of them received adjuvant radiotherapy or chemoradiation after surgery. Mean duration of patient s follow up was 82.4± 68.3 month. 5-year survival of our patients in all stages was 71%.Conclusions: Our findings are located between developed and underdeveloped countries. Our patients are diagnosed nearly in earlier stages of disease and 84.9 percent of them had surgery as a primary treatment, so earlier surgery resulted in good survival of patients.

Keywords:

vulvar cancer , radical surgery , chemoradiation , survival