Association of HLA-DQA1*0102, -DQB1*0602 haplotypes in in different genders of Khuzestan Province

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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CIGS15_228

تاریخ نمایه سازی: 13 بهمن 1398

Abstract:

Introduction: The human leukocyte antigen (HLA) system or complex is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. HLA are proteins or markers found on most cells in human body. Many studies show that MHC gene variants are associated with some diseases. This survey on Khuzestan population included the frequency of HLA haplotypes. HLA typing is used to match patients and donors for bone marrow or cord blood transplants; thus, reporting the association of HLA- DQA1*0102 and -DQB1*0602 haplotypes in normal population according to gender, were the goal of the study.Methods: This study included 242 healthy individuals without any disease. HLA-DQA1*0102, - and DQB1*0602alleles were genotyped, using the polymerase chain reaction amplification with sequence specific primers (PCR-SSP) method. The relationship of HLA alleles with gender examined. SPSS software was used for the statistical analyses. Result: DQB1*0602+-DQA1*0102+ as a two allelic haplotype showed no meaningful association with females compare with males (47.82% vs. 38.88%, p = 0.338, OR = 1.440 [95% CI = 0.681-3.046]). Conclusion: The study on resident in southwest of Iran gives some information about the HLA haplotype that has high frequency in both genders of this population. As DQB1*0602+-DQA1*0102+ haplotype has association with susceptibility to autoimmune diseases like MS, in some population; so, having high frequency of this haplotype may put the population in danger.

Authors

Nooshin delfan

Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Hamid Galehdari

Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Mohammad shafiei

Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Saieid Reza Khatami

Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Tahereh Seifi

Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Maryam Mohaghegh

Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.