STR Markers and Challenges of Interpretation in the Genetic Identification
Publish place: The Third International and 15th National Genetics Congress
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
CIGS15_454
تاریخ نمایه سازی: 13 بهمن 1398
Abstract:
Short tandem repeat (STR) markers have been used by the forensic genetics community since the mid-1990s to produce DNA profiles to answer questions in criminal investigations and relationship testing. We will examine the STR markers commonly used by the forensic genetics community along with configurations of commercial STR kits that impact interpretation in Genetic Identification. Many applications of forensic genetics deal with degraded DNA in small quantities. This issue happens especially in the extraction and analysis of DNA from skeletal samples such as bones or teeth. In this paper we focused on specific challenges and solutions to genetic data analysis of old, degraded bone samples. Kinship analysis such as Disaster Victim Identification and Familial Searching involve very large numbers of comparisons. We will discuss the particularities such as the possible search strategies, diagnosis of mutation, ways to handle partial or mixed profiles affected by allelic dropout, and drop-in.
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Authors
ali mir
Human Genetics Research Center, Baqiyatallah University of medical sciences, Tehran, Iran
sajjad Habibi Azarian
Human Genetics Research Center, Baqiyatallah University of medical sciences, Tehran, Iran
Hasan Bahmani,
Human Genetics Research Center, Baqiyatallah University of medical sciences, Tehran, Iran
Ebrahim Kiani,
Human Genetics Research Center, Baqiyatallah University of medical sciences, Tehran, Iran
Mahmood Tavallaie
Human Genetics Research Center, Baqiyatallah University of medical sciences, Tehran, Iran