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Transcriptomic profiling to identify biological processes involved in mastitis in dairy cattle.

تعداد صفحات: 1 | تعداد نمایش خلاصه: 64 | نظرات: 0
سال انتشار: 1397
کد COI Paper: CIGS15_482
زبان Paper: Englishglish
نسخه کامل Paper در کنفرانس ارائه نشده است و در دسترس نیست.

مشخصات نویسندگان Paper Transcriptomic profiling to identify biological processes involved in mastitis in dairy cattle.

Azadeh Torabi - Professor Assistant, Department of Agriculture, Payam Noor University (PNU), P.O.BOX, 19395-3697 Tehran, Iran.
Zahra roudbari - Department of Animal Science, University of Jioft, Jiroft, Iran
Hamidreza Seyedabadi - Department of Animal Biotechnology, Animal Science Research Institute of IRAN (ASRI), Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran

چکیده Paper:

Background: Mastitis is one of the health disorders with large effect on dairy farms and animal welfare it is caused by infection of pathogenic microorganisms such as Escherichia coli, Streptococcus uberis and Staphylococcus aureus. Alterations in milk composition, reduced milk quality and the production and treatment costs all contribute to the economic impact of this disease. Mastitis causes concern regarding both animal welfare and human health. For the development of effective strategies to control mastitis it is important to gain an in-depth understanding of the molecular mechanisms underlying the host immune response to the infection.Objective: the objective of this study was to identify the biological pathways affected in mastitis that show most gene expression changes in the bovine mammary gland that has an intramammary infection with E.coli using publicly available transcriptomic data.Methods: Transcriptomics data from Sipka et al was used in the present study (GSE50685). They measured gene expression in bovine mammary gland infected with E. coli. They compared gene expression after treatment with the antibiotic cefapirin and prednisolone with untreated bovine mammary gland tissue. Gene expression analysis was performed with the Affymetrix Bovine Genome Array. The data quality was evaluated and data normalization was performed using ArrayAnalysis.org. All arrays passed quality control and were analyzed further. Pathway analysis on differentially regulated genes was performed using PathVisio .Results: The regulation of mastitis is possibly the result of interaction of physiological and immunological processes which affects the bovine mammary tissue, identifying these processes with pathway analysis can help to understand mechanisms of cellular signaling pathways involving in mastitis. Pathway analysis revealed thirty-tree pathways that were significantly different (z-score > 1.96), ten of which were known to be involved in immune system regulation and metabolic pathway. Interestingly, IL-3, IL-6, TSLP, B cell receptor and Toll-like receptor signaling pathways which are known to be important in immune response, were enriched in the treated group. in these pathways, transcripts associated with immune response functions were downregulated.Conclusion: Results of the present study uncover pathways affected in the mammary gland infected E. coli that could help early detection and control measures for the prevention of E. coli mastitis, and thereby improve overall animal health and decrease economic losses to dairy farmers.

کلیدواژه ها:

Pathway analysis, Mastitis, Gene expression.

کد Paper/لینک ثابت به این Paper

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https://civilica.com/doc/983970/

کد COI Paper: CIGS15_482

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undefined, undefined و undefined, undefined و undefined, undefined,1397,Transcriptomic profiling to identify biological processes involved in mastitis in dairy cattle.,سومین کنگره بین المللی و پانزدهمین کنگره ملی ژنتیک ایران,Tehran,,,https://civilica.com/doc/983970

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1397, Torabi, Azadeh؛ Zahra roudbari و Hamidreza Seyedabadi)
برای بار دوم به بعد: (1397, Torabi؛ roudbari و Seyedabadi)
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