m zarei - Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
mostafa ghanei - Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
azam ahmadi - Department of Genetics, Arak University of Medical Sciences, Arak, Iran
mowla sj - Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Lung cancer is one of the most frequent cancers and is the leading cause of cancer-related death worldwide. Occurrence rate of this cancer depends on sex, geographical location, tobacco use, carcinogenic substances exposure.Histologically, lung cancer is classified into small cell and non-small cell lung cancer (SCLC,NSCLC). NSCLC is more commonand the cause of 85% of lung cancers. Forkhead box F1(FOXF1) gene is a member of FOX family. As a unique marker of precursor mesenchymal cells, it has a major role in development and restoration of lung. Considering the importance of FOXF1 gene, we aimed to investigate the expression of the gene in tumor vs. non-tumor tissues of lung. Bioinformatics analysis of 16q24.1 region using bioinformatics software including SSCprofiler, RNAfold, mipered, Mfold, iMiRNA-PseDPC, iMiRNA SSF, miRBase, was also employed to predict any potential microRNAs in this region. Our data suggest that the spliced variants of FOXF1 are differentially expressed in lung cancer. Further functional analysis is designed to investigate a potential biomarker/therapeutic application of the variants.

Lung Cancer, FOXF1, Bioinformatic Analysis