Zahra Sadaf - Department of Biology, Islamic Azad University, East Tehran Branch, Tehran, Iran
Pardis Sadat Tabatabaei Panah - Department of Biology, Islamic Azad University, East Tehran Branch, Tehran, Iran

The autoimmune disease is a disease that is spread by the immune system. Bullous pemphigoid (BP) is the most frequently occurring entity among autoimmune bullous skin diseases. and is clinically known, and superficial wounds in the skin before the plaques and local ulcers .Although the genetic determinants of BP have not been precisely elucidated, some studies have shown an association between a IL-17RA polymorphism (rs2229151) .Yet, these findings had so far not been independently replicated, and no data on a possible association of these mutations and BP in Iranian population were available.Methods This study contains 20 BP patients and 20 healthy controls. Genomic DNA was isolated using DNG-plus and PCR-RFLP analysis was performed to detect IL-17RA rs2229151 polymorphism. Several relevant information such as demographic data (age, gender …) or clinical characteristics were analyzed for a possible effect of these factors on susceptibility to BP in patients.Results There was no significant difference in genotypes of IL-17RA polymorphism (rs2229151) in both patients and control groups (p > 0.05). Conclusion This study did not showed an association between a IL-17A polymorphism (rs2229151) and BP disease in Iranian population. This results shows that the genetic predisposition to develop BP can greatly varies among different ethnic groups.

IL-17RA rs2229151, Bullous pemphigoid, Autoimmune disease,polymorphism