Investigating the effect of susceptible Transcription factor in progression of type 1 diabetes and autoimmune thyroid disease

Background: Genetic studies lead to identify mechanisms for detection of autoimmune diseases. The role of some similar genes has been identified in development of autoimmune diseases. Indeed, clinically distinct autoimmune diseases cluster in families, the existence of joint autoimmunity susceptibility genes. This association can be seen in autoimmune thyroid disease (AITD) and type 1 diabetes (T1D). AITD occurs in 10-25% of people with T1D. We aimed to identify the association between similar genes in the related mechanisms that trigger these two diseases.Method: We searched in PubMed with these keywords; diabetes, autoimmune thyroid disease, gene expression. Resulting was 52 articles from 2010-2018. The gene ontology (GO) of obtained genes figured out from DAVID (https://david.ncifcrf.gov/) (Table.1). The transcription factors (TF) were studied through TRRUST (http://www.grnpedia.org/trrust/) and RegNetwork (http://www.regnetworkweb.org/) databases. The association of TFs and genes were assessed. Interactions between genes and their TFs were drawn by GeneMANIA (https://genemania.org/) database.Result: Among 21 genes (deregulated 8 genes in AITD and 13 in T1D), 5 similar genes (HLA-DR3, HLA-DR4, PTPN22, CTLA4, FOXP3) play pathogenic roles in both diseases. Due to evaluated AITD and T1D process, PTPN22, CTLA4, FOXP3 are effectiveness in more process compare with HLA-DR3 and HLA-DR4. So 3 genes were selected and we obtained 48 TFs for these genes. NFATC2 as TF could regulating the expression of FOXP3 and CTLA4 genes(Fig1,2).Conclusion: The Results of our study showed that FOXP3 and CTLA4 genes promoting in AITD and T1D patients and NFATC2 regulating expression of mentioned genes.

Keywords:

Type 1 Diabetes , Autoimmune Thyroid Disease , Gene Expression , Bioinformatics Analysis and Transcription Factor.