Integrative computational analysis of potential miR-605 targetome and its pathways involved in cancer

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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CIGS15_565

تاریخ نمایه سازی: 13 بهمن 1398

Abstract:

MicroRNAs (miRNAs) are 19-25 nucleotide non-coding regulatory RNAs, that participate in a variety of developmental pathways and their deregulation has been implicated in the etiology of human cancers. Association of miR-605 with cancers has been stablished based on differential gene expression data sets and microRNA polymorphism studies. However, the major targetome of miR-605 has not clearly discovered.In this study target genes of miR-605 and pathways involved in were computationally analyzed. Computational prediction of target genes was done by multiMiR R package in the statistical software R. The multiMiR package finds targetome based on seven external servers including DIANA-microT-CDS, Microcosm, Miranda, miRDB, PicTar, PITA and target scan. The results showed the presence of 3263 unique target genes. In order to find and classify their biological functions and pathways we used DAVID bioinformatics resources and KEGG (Kyoto Encyclopedia of Genes and Genomes) server to classify these genes based on pathways that they were involved. Totally, we found 69 unique pathways for these 3263 genes. Among the pathways, 19 were involved in different signaling pathways in cancer that their dysregulation promote tumorigenesis, metastasis and angiogenesis. Predicted genes and pathways network showed that miR-605 could potentially be a tumor suppressor microRNA.

Authors

Arezu Kazemi

Division of genetics, Department of biology, Faculty of Science, University of Isfahan, Isfahan, IR Iran

Sadeq Vallian

Division of genetics, Department of biology, Faculty of Science, University of Isfahan, Isfahan, IR Iran