Manizheh Jalilvand - Cellular and Molecular research center, Qazvin University of medical Sciences, Qazvin, Iran
Javad Ansari - Cellular and Molecular research center, Qazvin University of medical Sciences, Qazvin, Iran
Reza Najafipour - Department of Biochemistry and Genetic, Cellular and Molecular research center, Qazvin,Universityof medical Sciences, Qazvin, Iran
Sahar Moghbelinejad - Department of Biochemistry and Genetic, Cellular and Molecular research center, Qazvin,Universityof medical Sciences, Qazvin, Iran
Mehrzad Ramezani - Cellular and Molecular research center, Qazvin University of medical Sciences, Qazvin, Iran
Masoumeh Alimohammadi - Cellular and Molecular research center, Qazvin University of medical Sciences, Qazvin, Iran

Structural chromosomal abnormalities are estimated to occur in around 0.5% of newborn infants. Chromosomes are the structures that hold our genes. If a chromosome or piece of a chromosome is missing or duplicated, there are missing or extra genes respectively. Many children with a chromosomal abnormality have mental and/or physical birth defects, ranging from mild to severe. In addition, some chromosomal abnormalities result in miscarriage or stillbirth. Chromosome disorders are of conditions, caused by constitutional numerical or structural abnormalities of chromosomes. Structural changes occur within the chromosomes themselves, not necessarily accompanied by any numerical change. There are varieties of chromosomal rearrangements that occur causing changes in the structure or components of a chromosome including: Translocations, Inversions, Ring chromosomes and Deletions.Materials and Methods: After blood sampling, culture, harvesting and preparation of metaphase spreads, we analyzed karyotype according to standard protocol in 3378 referred patients to the Genetic section of Reference Lab of Qazvin University of medical sciences during 2010-2017.Results: Our result shown 65 affected (23 translocations, 22 invesion, 4 deletion, 5 insertion, 2 ring chromosome, 14 inversion 9 (normal polymorphism) cases have chromosomal rearrangement.Discussions: Our result has shown chromosomal rearrangement were present in 1.9% of 3378 patients. In our results, the most frequent chromosome rearrangement observed is translocation similar other studies.

inversions; insertions; deletions; ring chromosomes; karyotype