Role of ferric nitrilotriacetate on croton oil induced mice skin inflammation and carcinogenesis

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

TOXICOLOGY15_075

تاریخ نمایه سازی: 15 بهمن 1398

Abstract:

Ferric nitrilotriacetate (Fe-NTA) is a potent oxidant and free radical generating agent.In this communication we report that topical application of Fe-NTA to mice skin exacerbates edema and skin tumorigenesis. Different groups of Albino Swiss mice treated with 7, 12-Dimethylbenz (a) anthracene (DMBA), croton oil or Fe-NTA for skin tissue inflammation and carcinogenesis.Fe-NTA dose dependently (6, 9 or 12 mg)/ 200 acetone/ mouse causes increased in edema size, hyperplasia, leukocytes infiltration. Also tumor incidences in group of animals receiving Fe-NTA, DMBA and croton oil were significantly increased.In conclusion our data suggest that Fe-NTA activates croton oil-induced pathogenic inflammation through release of arachidonic acid metabolites and oxidative stress generated by Fe-NTA is responsible for the croton oil-mediated skin carcinogenesis. However, the involvement of Fe-NTA on skin pathogenesis and tumorigeneis remains elusive and needs more experimentations.

Authors

Mohammad Ramazani

Department of Pharmacology and Toxicology, Tabriz University of Medical Sciences, Tabriz, Iran

Hassan Rezazadeh

Department of Pharmacology and Toxicology, Tabriz University of Medical Sciences, Tabriz, Iran

Ahad Bavili Tabrizi

Department Medical Chemistry, Faculty of Pharmacology, Tabriz University of Medical Sciences, Tabriz, Iran