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The acute and sub-acute cardiotoxicity effects of the Persian Gulf upside-down jellyfish ‘‘Cassiopea sp. ‘‘venom

تعداد صفحات: 1 | تعداد نمایش خلاصه: 85 | نظرات: 0
سال انتشار: 1398
کد COI Paper: TOXICOLOGY15_116
زبان Paper: Englishglish
نسخه کامل Paper در کنفرانس ارائه نشده است و در دسترس نیست.

مشخصات نویسندگان Paper The acute and sub-acute cardiotoxicity effects of the Persian Gulf upside-down jellyfish ‘‘Cassiopea sp. ‘‘venom

Iraj Nabipour - The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran
G Hosseini Mohebbi - The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran
Hossein Vatanpour - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shaheed Beheshti Medical Sciences University, Tehran 615314155, Iran
Amir Vazirizadeh - Department of Marine Biotechnology, The Persian Gulf Research and Studies Center, The Persian Gulf University, Bushehr 7516913817, Iran
Hamideh Dehghani - The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran
Masoud Zare - The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran- Marine Pharmaceutical Science Research Center, Ahvaz Jundishapur University of Medical Sc

چکیده Paper:

Introduction: Cardiovascular toxicities are considered the major toxic effect of some jellyfish venoms. In the present study, crude venom from the Persian Gulf upside-down jellyfish ‘‘Cassiopea sp. for acute and sub-acute cardiotoxicity, were studied.Methods: The acute and sub-acute toxicity of the venom from the alien Cassiopea andromeda jellyfish were studied in rat respectively at 60min and 21 days after exposure. For acute study, direct cardiotoxicity of the venom was assessed by a Langendorff isolated perfused rat heart system. Treatments were performed with concentrations of 50, 20, 10, 5, and 2.5 μg/ml of venom on isolated rat hearts for 60 min. Then, the hemodynamic parameters of heart rate, left ventricular end-diastolic pressure, left ventricular systolic pressure, left ventricular developed pressure, and coronary flow were evaluated. Lactate dehydrogenase (LDH) levels as well as histopathological examinations were also investigated. Moreover, for sub-acute toxicity on the heart, three doses of crude venom (0.0125, 0.025 and 0.05 μg/ml/day) were administered intraperitoneally to the rats, once daily for 21 days.Results: Based on the ECG findings, treatments in a dose-dependent pattern changed cardiac electrical activity and decreased coronary effluent. The higher concentrations of venom produced severe bradycardia, atrioventricular dissociation, complete atrioventricular block, and ultimately cardiac arrest. Ventricular end-diastolic pressure was also significantly increased by high concentrations of venom. At high venom concentrations, scatter lymphocytic infiltration and wavy fibers were found in the histopathological examinations. Treatment with concentrations of 2.5–10 μg/ml caused a considerable increase in LDH levels within 30 min compared with baseline levels. Histopathological examinations of the rat heart tissues indicated that there were different demonstrable abnormalities and alterations in the microscopic examinations in comparison to their control groups, especially at a higher dose of 0.05 μg/ml/dayConclusion: In conclusion, venom from the Persian Gulf upside-down jellyfish had significant direct and sub acute cardiotoxicity effects on isolated rat hearts. The jellyfish crude venom contains compounds that may affect cardiac contraction, heart rate, and blood pressure.

کلیدواژه ها:

Upside-down Jellyfish, Cassiopea andromeda, Cardiotoxicity, acute, sub-acute, Venom

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https://civilica.com/doc/984980/

کد COI Paper: TOXICOLOGY15_116

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undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,The acute and sub-acute cardiotoxicity effects of the Persian Gulf upside-down jellyfish ‘‘Cassiopea sp. ‘‘venom,پانزدهمین همایش سراسری سم شناسی ایران,Tehran,,,https://civilica.com/doc/984980

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برای بار اول: (1398, Nabipour, Iraj؛ G Hosseini Mohebbi و Hossein Vatanpour و Amir Vazirizadeh و Hamideh Dehghani و Masoud Zare)
برای بار دوم به بعد: (1398, Nabipour؛ Hosseini Mohebbi و Vatanpour و Vazirizadeh و Dehghani و Zare)
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