Evolution and comparison effects of Fludrocortisone and Betamethasone on Glucose and lipid profile in rat

Introduction: Diabetes mellitus is the most common disease due to metabolic disorder. Hyperglycemia that is associated with insufficient insulin secretion, impaired insulin function, or both is one of the common adverse effects of corticosteroids. Researchers suggest that rational consumption of corticosteroids result in proper control of blood glucose and lipid disorders, can delay the onset and progression of complications from the disease In this study effects of Fludrocortisone and Betamet.Materials and Methods: This is an experimental study. It was used 40 male Wistar rats from Yazd Animal infertility center. Initially, the rats were randomly divided into 2 groups and then each group divided into 4 groups. Subsequently, fludrocortisone doses of 12 mg / kg, 24 mg / kg and 36 mg / kg were administered to rats, and dosages of 6 mg / kg, 12 mg / kg, and 18 mg / kg for betamethasone administered to rats on a daily basis at 1 o clock for 21 days by intraperitoneally injection.Results: Betamethasone and Fludrocortisone increased blood glucose and AST, ALT, TG, LDL, VLDL, and decreased HDL. In all of the measured factors, flodecortisone changes were more than betamethasone. Fludrocortisone and betamethasone also had significant effects on weight, which was more pronounced with fludrocortisone.Discussion and Conclusion: As the dose increased, the levels of AST, ALT, and cholesterol, TG, VLDL and LDL in the blood increased significantly and HDL levels decreased more in the blood, but fludrocortisone showed a stronger effect than betamethasone. Therefore, it can be expected that the use of betamethionone would be logical due to fewer side effects than Fludrocortisone.

Keywords:

Fludrocortisone , Betamethasone , Fat Profile , Glucose , Type 2 Diabetes