DNA Damage Induced by Mobile Radiation Exposure in Pregnant Mice
Publish place: 15th iranian congress of toxicology
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
TOXICOLOGY15_136
تاریخ نمایه سازی: 15 بهمن 1398
Abstract:
Introduction: Daily application of various devices like microwave, mobile phone, medical devices and etc. would put people in the risk of electromagnetic radiation exposure. As a non-thermal effects of electromagnetic waves on human cells, exposure to mobile radiation cause in generation of reactive oxygen species, which is resulted in oxidative stress. The most used frequency in GSM, global system for mobile communication, in Asia, is 900 MHz. This study has investigated the effects of mobile phone (915 MHz) – induced electromagnetic radiation on DNA damage and TAC in blood of pregnant mice and the preventive role of vitamin C as an antioxidant.Materials and Methods: 21 pregnant mice were divided into 3 groups (control, exposure and exposure plus vitamin). The exposure groups were exposed to mobile phone radiation (915 MHz and 0.045 μw/cm2 power density, 8 h/d for 10 days) during pregnancy. The exposure plus vitamin group was received vitamin C (200 mg\Kg) by gavage. After 5 days, the mice were anesthetized and their blood samples were collected from the heart. 8-OHdG and TAC were measured by analytical commercial kits. All data were analyzed by ANOVA-Tukey test using SPSS (24.)Results: Significant increase in 8-OHdG levels were observed in exposure group (42.439± 1.3 ng/ml) compare to control (36.29±1.92 ng/ml) and exposure plus vitamin C groups (31.051±1.046 ng/ml). The TAC levels in exposure group (0.054±0.003mM) and exposure plus vitamin C group (0.068±0.001mM) had a significant decrease compare to the control group (0.082±0.004mM) (p = 0.001).Conclusion: Electromagnetic radiation caused DNA damage in blood of pregnant mice RFR caused oxidative stress in pregnant mice and increased DNA damage biomarker level and changes in TAC level. Consumption of vitamin C could prevent these changes in some extent. Studies on non-ionizing radiation during pregnancy will help define threshold limit for its exposure for pregnant women and protect them.
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Authors
Nargess Moghadasi
Department of Occupational Health Engineering, School of Public Health, Iran University of Medical Science, Tehran, Iran
Ali Safari Variani
Department of Occupational Health Engineering, School of Public Health, Qazvin University of Medical Science, Qazvin, Iran
Agha Fatemeh Hosseini
Department of Biostatistics, School of Public Health, Iran University of Medical Science, Tehran, Iran
Azadeh Ashtarinezhad
Air Pollution Research Center, Department of Occupational Health Engineering, School of Public Health, Iran University of Medical Science, Tehran, Iran