Cisplatin is a chemotherapy drug that treats a wide range of solid tumors. However, its clinical use is due to renal failure and a reduction in glomerular clearance of 15 to 30% of patients are limited. Several mechanisms that contribute to
cisplatin in kidney dysfunction include the damage to tubular epithelial cells, shrinkage in small kidney vessels, and an increase in the incidence of pre-inflammatory cytokines. The accumulation of
cisplatin in the kidney and the resulting renal damage depends on the amount of
cisplatin renal secretion through the multidrug and toxin protein 1 (MDR1) and (oct2) organic cation transporter2. Cimetidine, an antagonist of H2 histamine, by controlling the OCT transporter, effectively eliminates or reduces the effects of
cisplatin induced auto-toxicity and nephrotoxicity. Considering the fact that in many chemotherapy protocols today,
cisplatin is used and due to the prevalence of kidney failure and the importance of its prophylactic measures, this study to investigate the effects of the improvement of the cimetidine,
ranitidine and famotidine drugs on the damage to the kidney system was at the same time as cisplatin. This study examined the impact of cimetidine, Ranitidin and Famotidine supplementation on kidney as a major targets of
cisplatin -induced toxicity. Ratsreceived cisplatin+cimetidine (50،100 mg/kg) ،cisplatin+ Ranitidin (25،50 mg/kg) and cisplatin+ famotidine (20 mg/kg). Blood and kidney samples were collected at scheduled time interval. Serum biomarkers, along with markers of oxidative stress in the kidney tissue was evaluated. Cisplatin toxicity was evident in rats as a significant elevation in markers of oxidative stress. Kidney injury was histopathologically evident by inflammation and hemorrhage. Furthermore, high level of reactive oxygen species (ROS), lipid peroxidation (LPO), depleted glutathione reservoirs, and impaired tissue antioxidant capacity were also detected in the kidney of that rats received cisplatin. However, cimetidine, Ranitidin and Famotidine supplementation decreased ROS, and LPO. Meanwhile, it was found that cimetidine, ranitidin and famotidine supplementation attenuated oxidative stress markers in the kidney of treated animals with cisplatin. Moreover, kidney histopathological changes were markedly mitigated by cimetidine, ranitidin and famotidine treatment. The mechanisms for the beneficial effects of cimetidine, ranitidin and famotidine administration in treated animals might be linked to its ability for preserving cellular redox environment, preventing oxidative stress.