ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

The ameliorative effects of phenylmethylsulfonyl fluoride on morphine tolerance and dependence in mice

Year: 1398
COI: TOXICOLOGY15_232
Language: EnglishView: 232
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Ehsan Asadi Akbarabadi - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Hossein Rajabi Vardanjani - Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
Shahrzad Molavinia - Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran- Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Marzieh Pashmforoosh - Behbahan Faculty of Medical Sciences, Behbahan, Iran
Mohammad Javad Khodayar - Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran- Department of Toxicology, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract:

Introduction: Opioids use such as morphine has been limited due to tolerance and dependence as major unwanted effects of opioids. Previous evidence has shown that targeting endocannabinoid signaling can prevent the development of opioid tolerance and dependence. Accordingly, this study was designed to evaluate the effect of phenylmethylsulfonyl fluoride (PMSF) an inhibitor of fatty acid amide hydrolase (FAAH) on morphine antinociceptive tolerance and physical dependence in mice.Materials and Methods: The antinociceptive effects of PMSF at the doses 60, 120 and 300 mg/kg were investigated. The dose of (60 mg/kg, i.p.) of PMSF is defined as subeffective dose. Morphine tolerance and dependence were induced by twice daily injection of morphine (10 mg/kg, s.c.) for 10 consecutive days and the last dose on day 11. Tolerance was assessed by the hot-plate test and dependence by naloxone-precipitated morphine withdrawal signs including jumping and weight loss. In the brain, oxidative stress markers include activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase and levels of malondialdehyde (MDA) and glutathione (GSH) were determined.Results: These results showed that PMSF has notable antinociceptive effect at the doses 120 and 300 mg/kg. A sub-antinociceptive dose (60 mg/kg) of PMSF could reduce tolerance in both acute and chronic methods of administration. However, alleviation of dependence and suppression of oxidative stress markers occurred in the chronic administration of PMSF.Discussion and Conclusion: PMSF in chronic use with morphine can reduce the induction of tolerance and dependence. Acute co-administration of PMSF with morphine was accompanied with the alleviation of morphine tolerance but had no effect on dependence and oxidative stress. These effects of PMSF may be related to increases in endocannabinoid levels, and consequently contributing to the opioids system in the suppression of morphine tolerance and dependence.

Keywords:

Paper COI Code

This Paper COI Code is TOXICOLOGY15_232. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/985094/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Asadi Akbarabadi, Ehsan and Rajabi Vardanjani, Hossein and Molavinia, Shahrzad and Pashmforoosh, Marzieh and Khodayar, Mohammad Javad,1398,The ameliorative effects of phenylmethylsulfonyl fluoride on morphine tolerance and dependence in mice,15th iranian congress of toxicology,Tehran,https://civilica.com/doc/985094

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: علوم پزشکی
Paper count: 3,152
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

New Papers

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support