Preparation, quality control and biodistribution study of 68Ga-BPAMD: Optimized production with an in-house 68Ge-68Ga generator

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
View: 368

This Paper With 5 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IRJNM-26-2_003

تاریخ نمایه سازی: 19 بهمن 1398

Abstract:

Introduction: Bone metastases are common in the progression of various tumors leading to severe pain and decrease in quality of life. The aim of this study was to optimize the production of 68Ga-BPAMD as an ideal bone imaging agent using an in-house 68Ge/68Ga generator for future clinical use. Methods: The optimized conditions for the preparation of 68Ga-BPAMD were determined by varying ligand concentration, pH, time and temperature. The radiochemical purity of the complex was checked using ITLC method. The stability at room temperature and in human serum and the hydroxyapatite (HA) binding of the complex were studied. Biodistribution of 68Ga-BPAMD and 68GaCl3 were investigated in male Syrian rats. Results:The radiolabelled compound was prepared with a radiochemical purity of > 99% after 15 min at the optimized conditions (30 µg of ligand, 90 °C, pH=3-5). The complex was stable in the final preparation and in the presence of human serum (> 98%). HA binding assay demonstrated that at the amount of 10 and 25 mg of HA, 62.3 and 88.5 % of the complex are bound to HA, respectively. The agent demonstrated significant accumulation in the bone tissue, while cleared very fast from blood circulation. Major difference in uptake between 68Ga-BPAMD and 68GaCl3 was observed especially in blood, bone, liver, and spleen which can be considered as favorable characteristics of this agent. Conclusion: According to these results, this agent can be produced with the recently developed in-house generator and considered as a worthy bone PET imaging agent available for further clinical use.

Authors

Ali Rabie

Energy Engineering and Physics Department, Amirkabir University of Technology, Tehran, Iran

Hassan Yousefnia

Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Samaneh Zolghadri

Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Mojtaba Shamsaei

Energy Engineering and Physics Department, Amirkabir University of Technology, Tehran, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Singh VA, Haseeb A, Alkubaisi AA. Incidence and outcome of ...
  • Kuchuk I, Hutton B, Moretto P, Ng T, Addison CL, ...
  • Cook GJ, Azad GK, Goh V. Imaging bone metastases in ...
  • Heindel W, Gübitz R, Vieth V, Weckesser M, Schober O, ...
  • Cuccurullo V1, Cascini GL, Tamburrini O, Rotondo A, Mansi L. ...
  • Nilegaonkar S, Sonar S, Ranade A, Khadilkar M.  TC99m MDP ...
  • Araz M, Aras G, Küçük ÖN.  The role of 18F-NaF ...
  • Banerjee SR, Pomper MG. Clinical applications of Gallium-68. Appl Radiat ...
  • Jalilian AR. An overview on Ga-68 radiopharmaceuticals for positron emission ...
  • Naderi M, Zolghadri S, Yousefnia H, Ramazani A, Jalilian AR. ...
  • Fellner M, Baum RP, Kubícek V, Hermann P, Lukes I, ...
  • Mirzaei A, Jalilian AR, Aghanejad A, Mazidi M, Yousefnia H, ...
  • Aghanejad A, Jalilian AR, Maus S, Yousefnia H, Geramifar P, ...
  • Yousefnia H, Zolghadri S, Jalilian AR. Preparation and biodistribution assessment ...
  • Doroudi A, Saadati SM, Ahmadi F, khodayar J, Rezaee S, ...
  • Fellner M, Baum RP, Kubícek V, Hermann P, Lukes I, ...
  • نمایش کامل مراجع