Preparation and quality control of 177Lu-chitosan for radiosynovectomy
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Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy
(RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Several radiopharmaceuticals have been developed for RSV so far, but still development of new radiophamaceuticals is of crucial interest. In this research, the 177Lu-chitosan complex (177Lu-CHITO) was introduced as a new agent for RSV.
Methods: 177Lu was produced by irradiation of a natural Lu2O3 target at a thermal neutron flux of approximately 4 × 1013 n/cm2·s. 177Lu-CHITO was prepared in the diluted acetic acid solution. The radiochemical yield was checked by ITLC method. The biodistribution of the complex was investigated by intra-articular injection to rabbits’ and rats’ knee joints. The leakage of injected dose from the injection site in the rabbit organs was investigated using SPECT
imaging up to 48 hours.
Results: 177Lu was prepared with a specific activity of 2.6-3 GBq.mg-1 and radionuclide purity of 99.98%. 177Lu-CHITO was prepared successfully with high radiochemical purity (95%) and specific activity of 888 TBq/mmol. Both the biodistribution data in rats and SPECT
imaging of the rabbit showed that there was no significant leakage of the injected activity even after 192 h.
Conclusion: Considering all of the excellent features of the complex, this radiopharmaceutical can be used for effective management of synovial inflammation.
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Yousefnia, Hassan and Jalilian, Amir and Abbasi-Davani, Fereydoun and Zolghadri, Samaneh,1393,Preparation and quality control of 177Lu-chitosan for radiosynovectomy,https://civilica.com/doc/986619
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Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and ...Grossman JM, Brahn E. Rheumatoid arthritis: current clinical and research ...Schneider P, Farahati J, Reiners C. Radiosynovectomy in rheumatology, orthopedics, ...Unni PR, Chaudhari PR, Venkatesh M, Ramamoorthy N, Pillai MR. ...Kampen WU, Hellweg L, Massoudi-Nickel S, Czech N, Brenner W, ...Kothari K, Suresh S, Sarma HD, Meera V, Pillai MR. ...Mäkelä O, Penttilä P, Kolehmainen E, Sukura A, Sankari S, ...Clunie G, Lui D, Cullum I, Edwards JC, Ell PJ. ...Pirich C, Wanivenhaus A, Graninger W, Kvaternik H, Angelberger P, ...Das T, Pillai MR. Options to meet the future global ...Chakraborty S, Das T, Banerjee S, Sarma HD, Venkatesh M. ...Chakraborty S, Das T, Sarma HD, Venkatesh M, Banerjee S. ...Brodack JW, Chinen LK, Deutsch E, Deutsch KF. Studies on ...Harish Prashanth KV, Tharanathan RN. Chitin/chitosan: modifications and their unlimited ...Rinaudo M. Chitin and chitosan: Properties and applications. Prog Polym ...Suzuki YS, Momose Y, Higashi N, Shigematsu A, Park KB, ...Shin BC, Park KB, Jang BS, Lim SM, Shim CK. ...Industrial Applications and Chemistry Section, International Atomic Energy Agency. Manual ...Chakraborty S, Das T, Banerjee S, Subramanian S, Sarma HD, ...Sledge CB, Noble J, Hnatowich DJ, Kramer R, Shortkroff S. ...Davis MA, Chinol M. Chinol M. Radiopharmaceuticals for radiation synovectomy: ...Johnson LS, Yanch JC, Shortkroff S, Barnes CL, Spitzer AI, ...Boussina I, Toussaint M, Ott H, Hermans P, Fallet GH. ...Kahan A, Mödder G, Menkes CJ, Verrier P, Devaux JY, ...Gratz S, Göbel D, Behr TM, Herrmann A, Becker W. ...Clunie G, Fischer M; EANM. EANM procedure guidelines for radiosynovectomy. ...Prabhakar G, Sachdev SS, Umamaheswari S, Sivaprasad N, Bhatia MH, ...