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Title

Preparation and quality control of 177Lu-chitosan for radiosynovectomy

Year: 1393
COI: JR_IRJNM-22-1_001
Language: EnglishView: 154
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Authors

Hassan Yousefnia - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran (AEOI), Tehran, Iran
Amir Jalilian - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran (AEOI), Tehran, Iran
Fereydoun Abbasi-Davani - Radiation Application Group, Faculty of Nuclear Engineering, Shahid Beheshti University, Tehran, Iran
Samaneh Zolghadri - Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran (AEOI), Tehran, Iran

Abstract:

Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Several radiopharmaceuticals have been developed for RSV so far, but still development of new radiophamaceuticals is of crucial interest. In this research, the 177Lu-chitosan complex (177Lu-CHITO) was introduced as a new agent for RSV. Methods: 177Lu was produced by irradiation of a natural Lu2O3 target at a thermal neutron flux of approximately 4 × 1013 n/cm2·s. 177Lu-CHITO was prepared in the diluted acetic acid solution. The radiochemical yield was checked by ITLC method. The biodistribution of the complex was investigated by intra-articular injection to rabbits’ and rats’ knee joints. The leakage of injected dose from the injection site in the rabbit organs was investigated using SPECT imaging up to 48 hours. Results: 177Lu was prepared with a specific activity of 2.6-3 GBq.mg-1 and radionuclide purity of 99.98%. 177Lu-CHITO was prepared successfully with high radiochemical purity (95%) and specific activity of 888 TBq/mmol. Both the biodistribution data in rats and SPECT imaging of the rabbit showed that there was no significant leakage of the injected activity even after 192 h. Conclusion: Considering all of the excellent features of the complex, this radiopharmaceutical can be used for effective management of synovial inflammation.

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Paper COI Code

This Paper COI Code is JR_IRJNM-22-1_001. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/986619/

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Yousefnia, Hassan and Jalilian, Amir and Abbasi-Davani, Fereydoun and Zolghadri, Samaneh,1393,Preparation and quality control of 177Lu-chitosan for radiosynovectomy,https://civilica.com/doc/986619

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