Preparation and quality control of scandium-46 bleomycin as a possible therapeutic agent
عنوان مقاله: Preparation and quality control of scandium-46 bleomycin as a possible therapeutic agent
شناسه ملی مقاله: JR_IRJNM-20-1_004
منتشر شده در شماره 1 دوره 20 فصل در سال 1391
شناسه ملی مقاله: JR_IRJNM-20-1_004
منتشر شده در شماره 1 دوره 20 فصل در سال 1391
مشخصات نویسندگان مقاله:
Leila Moghaddam-Banaem - Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, Tehran, Iran
Amir Jalilian - Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, Tehran, Iran
Mohammadreza Pourjavid - Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, Tehran, Iran
Ali Bahrami-Samani - Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, Tehran, Iran
خلاصه مقاله:
Leila Moghaddam-Banaem - Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, Tehran, Iran
Amir Jalilian - Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, Tehran, Iran
Mohammadreza Pourjavid - Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, Tehran, Iran
Ali Bahrami-Samani - Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Atomic Energy Organization of Iran, Tehran, Iran
Introduction: Due to interesting therapeutic properties of 46Sc and antineoblastic antibiotic, bleomycin (BLM), 46Sc-bleomycin (46Sc-BLM) was developed as a possible therapeutic compound.
Methods: In this work, Sc-46 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of natural metallic scandium sample followed by dissolution in acidic media as a substitute for 47Sc in radiolabeling studies which was further used for labeling of bleomycin (BLM) followed by stability studies as well as biodistribution in wild-type rats.
Results: Sc-46 was obtained in high radiochemical purity (ITLC, > 99%, two systems) as well as acceptable specific activity. At optimized conditions a radiochemical purity of 98% was obtained for 46Sc-BLM shown by ITLC (Specific activity, 740 GBq/mmole). The accumulation of the radiolabeled compound in lungs, liver and spleen demonstrates a similar pattern to the other radiolabeled bleomycins.
Conclusion: Sc-BLM is a possible therapeutic agent in human malignancies and the efficacy of the compound should be tested in various tumor-bearing models.
کلمات کلیدی: Bleomycin, Sc-46, Biodistribution, Radiolabeling
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/986653/