Sentinel node detection failure due to defective labeling and large particle size of Tc-99m antimony sulfide colloid
Publish place: Iranian Journal of Nuclear Medicine، Vol: 19، Issue: 1
Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IRJNM-19-1_001
تاریخ نمایه سازی: 21 بهمن 1398
Abstract:
Introduction: Many radiotracers have been used for sentinel node mapping with acceptable results. The main difference between these radiotracers is the particle size. In the current study, we reported defective labeling of Tc-99m antimony sulfide colloid which resulted in large particle size. Methods: Tc-99m-Antimony sulfide colloid was used for axillary sentinel node mapping of 45 breast cancer patients. The prepared kits were turbid and were used for the first 15 patients. For the remaining 30 patients, we used a filter (GyroDisc CA-PC Cellulose Acetate Membrane; 30 mm; Pore size: 0.2 µm) after labeling to remove the possible large particles of the prepared kits. Results: On the lymphoscintigraphy images, at least one sentinel node could be identified in 5 and 29 patients of the unfiltered and filtered groups respectively (p=0.00001). Sentinel node detection by gamma probe was successful in 5 and 30 patients in the unfiltered and filtered groups respectively (p=0.000001). Conclusion: Tc-99-Antimopny sulfide colloid is a suitable radiotracer for sentinel node mapping of the breast cancer patients. In case of any unusual turbidity of the labeled kit, it should not be used or at least be filtered before injection.
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Authors
Keyvan Sadri
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Narjes Khatoon Ayati
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Gholamali Shabani
Nuclear Science Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran (AEOI), Tehran, Iran
Seyed Rasoul Zakavi
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran