Three Years Cross Sectional Study on Resistant Nosocomial Infections at Shiraz burn center

Introduction and objectives: Nosocomial infection and drug resistance against them are a global concern in the worldwide. Recently invasive infection is associated strongly with mortality and morbidity rate, especially in immunosuppressive patients like burned victims. So knowledge about burn infection and antibiotic susceptibility pattern can contribute to the effective control of infection. The current study investigates the prevalence of infectious agent and antibiotic resistant pattern in order to improve treatment policy in burn patients. Materials and methods: This cross sectional study was conducted during April 2016 to March 2019 in Amir-Al momenin burn center affiliated with Shiraz University of Medical Sciences. A total number of 1180 samples were taken from blood, urine, stool, wound and evaluated to detect the most prevalent infections during 3 years. Patients with sustained deep burns (degree 2 and more) included in the study. Results: Out of 1180 patients, 60.8% were males while 39.2% were females. Patient s age range from 1 to 89 years with mean 32.07 ±20.88 .According to infectious agent; Pseudomonas aeruginosa was the most frequent isolates (46.9%) followed by Klebsiella (11.3%) and Acinetobacter Baumannii (6.8%). Based on the sensitivity pattern; highest resistance against P.aeruginosa and Klebsiella was Ciprofloxacin which was estimated 40.93 and 7.28% respectively. The antibiotics to which A. Baumannii was most resistance was Imipenem and Ceftazidime (5.93%) Conclusion: A major barrier to the treatment of nosocomial infections is the increase in antibiotic-resistant organisms especially for burn victims. Hand hygiene, considering stewardship program and especial attention to infection control programs will help to improve the patient’s surveillance.

Keywords:

Nosocomial infection , antibiotic-resistance , Burn Patients , Shiraz.