The prevalence of Fusobacterium nucleatum among healthy individuals admitted gastroscopy clinic at Tehran, Iran

Introduction: Fusobacterium nucleatum is an anaerobic microbe that was supposed to be a member of normal human commensal flora. Following the great discovery on Helicobacter pylori and its reported association with occurrence of gastric cancer, now it claimed that colorectal cancer may be directly associated with individuals colonized with Fusobacterium nucleatum. The purpose of our study is to examine the primary existence of this bacterium among the healthy patients using PCR method.Materials and methods: In a cross-sectional study, we have examined the colorectal biopsy specimen from the eight consecutive candidates who referred to the gastroscopic clinic, Tehran, Iran. PCR approach was used as diagnostic method in this study. A chi-square test was used to analyze the possible association between presence of Fusobacterium nucleatum and diagnosed disease. All measurements of significance were two‐tailed with a P‐value of < 0.05 in our analysis. Results: None of our suspected biopsy samples were infected with Fusobacterium nucleatum using our detection approach (P value > 0.05). Conclusions: Fusobacterium nucleatum is an identified pathogenic bacterium implicated in IBD and is overrepresented in colorectal tumors. However, in our investigation F. nucleatum was not observed in healthy individuals. Current findings suggested that F. nucleatum may be associated with the progression of gastroenterological diseases include colorectal cancer pending new through and accurate experiments confirming current shaped conclusion.

Keywords:

Fusobacterium nucleatum , colorectal cancer , PCR method , healthy individuals