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Inhibition of mouse colon cancer growth following immunotherapy with hydatid cyst fluid and BCG

عنوان مقاله: Inhibition of mouse colon cancer growth following immunotherapy with hydatid cyst fluid and BCG
شناسه ملی مقاله: MEDISM20_278
منتشر شده در بیستمین کنگره بین المللی میکروب شناسی ایران در سال 1398
مشخصات نویسندگان مقاله:

Shahla Rostamirad - Clinical research development center, Najafabad Branch, Islamic Azad university,Najafabad,Iran
Mohammadreza Mofid - Department of Biochemistry, Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Alireza Andalib - Department of immunology, Isfahan medical school, Isfahan University of Medical Sciences, Isfahan, Iran.
Hossein Yousofi Darani - Cancer Prevention Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.

خلاصه مقاله:
Introduction and Objectives: Hydatid cyst located in human and livestock viscera is the larval stage of Echinococcus granulosus tape worm. Scientific evidences indicating that certain Parasitic Infections may induce antitumor activities against some types of cancers. In this research work, the effects of a hydatid cyst fluid and BCG on colon cancer tumor growth in BALB/c mice have been studied. Materials and methods: For this purpose, four groups of mice were injected with colon cancer cells. After 5 days when the sign of tumor growth in mice was seen, group 1&2 were injected with hydatid cyst fluid and BCG respectively. Groups three were injected with only adjuvant and the fourth group left intact without any injection. The size of the tumor was measured and compared in all groups. Then blood samples of mice were evaluated for serum cytokine levels. Results: In mice injected with hydatid cyst fluid and BCG tumor size were smaller than those of control groups and the difference was statistically significant.Conclusion: The results of this work indicated that injection of a hydatid cyst fluid and BCG significantly inhibited mouse colon cancer growth and this inhibition may be related to effect of immune response to these antigens.

کلمات کلیدی:
Colon cancer, cytokine, Echinoccocus granolosus, hydatid cyst fluid, BCG

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/987394/