Distribution of Mycoplasma hominis in Prostate Cancer Reffered to Hamadan Shahid Beheshti Hospital in 2018

Introduction and Objectives: Mycoplasma hominis is an opportunistic pathogen in the human genital tract and is capable of causing chronic infection in the prostate gland. The long-term relationship between bacteria and host cells can have reciprocal effects, the most important of which is the effect of bacteria on the cell growth cycle. Considering the importance of prostate cancer, the association of this bacterium with prostate cancer has been investigated in this project. Materials and Methods: In this study, thin sections of 61 prostate biopsy blocks of patients with prostate cancer and 70 prostate biopsy blocks were obtained from patients with Benign Prostatic Hyperplasia. DNA were extracted from all samples and amplified by real-time PCR targeting 16S rRNA and yidC genes. Results: Out of 61 samples of prostate biopsy in patients with prostate cancer, 7 cases (11.4%) were positive for Mycoplasma hominis infection; while the bacterium was not detected in any sample of patients with Benign Prostatic Hyperplasia. Conclusion: However, further studies are needed to prove the role of Mycoplasma hominis in the development of prostate cancer, but due to the significant relationship between the associations of this bacterium in patients with prostate cancer, it is necessary to detect this organism in the genitourinary tracts of men and infected people should be treated immediately.

Keywords:

Mycoplasma hominis , Prostate Cancer , Benign Prostatic Hyperplasia