Seyed Zia Hejripor Rafsanjani - Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran
Saeed Shiralizadeh - Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran
Masoud Shahabian - Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran
Gholamhosein Bagheri - Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran

Background and Aim : The aim of this study was to compare the effect of pulmicort and systemiccorticosteroids on the treatment of patients with acute obstructive pulmonary attack (AOPA) bycontrolling confounding factors (age and sex)Methods : This study was a double-blind clinical trial performed on 72 patients with AOPA inBesat Hospital, Tehran, Iran from 20 March 2016 to 20 March 2017. Patients were randomlyassigned into two treatment groups of nebulized pulmicort (budesonide) or systemiccorticosteroids using prednisolone 50 mg or hydrocortisone 200 mg. To test the main hypothesisof the research, logistic regression analyzes were performed while Chi-square and Fisher exacttests were used to tests the sub-hypotheses of the study in SPSS 21.Results : The odds of recovery in patients who received pulmicort was 6.68 times higher than thesystemic corticosteroids treatment group (Odds ratio (OR) = 6.68, P-value = 0.003). The odds ofrecovery in women was 11.48 times higher than men (OR = 11.48, P-value = 0.000). 0.94 odds ofrecovery in older aged patients compared with lower ages showed that the chance of remissionreduces with aging. (OR = 0.94, P-value = 0.002). According to 2 independent sample t-test, thedifference in pt recovery on the basis of age was significant only in the patient who receivedpulmicortConclusion : Based on the results of this study, pulmicort was more effective than systemiccorticosteroid in the treatment of patients with AOPA regardless of their gender

Acute obstructive pulmonary attack, Pulmicort, Systemic corticosteroid