Maryam Massaeli - Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran
Ahmadreza Khazaee - Department of Emergency Medicine, Golestan Navy Hospital, Tehran, Iran
Masoud Shahabian - Department of Emergency Medicine, AJA University of Medical Sciences, Tehran, Iran

Background and Aim : Renal colic is an acute syndrome for which relieving the pain is knownto be the best treatment. Te aim of this randomized clinical trial was comparing the efcacy ofintravenous ketorolac with intravenous morphine sulfate in relieving the acute pain of renal colicin patients referred to the emergency department of a tertiary care teaching hospital.Methods : 98 cases were selected via convenience sampling method from patients with apresumptive diagnosis of renal colic admited in the emergency department of Besat Nahajahospital of Tehran, Iran from March to May 2014 and randomly divided into two groups of equalsize, ketorolac, and morphine sulfate. Te patients’ vital signs and pain intensity were observed atbaseline of the study and afer 10, 30, 60, 120 and 180 minutes of drug administration. Patientswere also followed for side eff ects. Te areaunder-the-curve (AUC) was used for pain assessment.Data were analyzed in SPSS 19 using T- test, Chi-square test, and Mann-Whitney test atsignifcance level < 0.05Results : Demographic and clinical characteristics of the two groups were similar before drugadministration. Both drugs were equally eff ective in reducing pain over time (P-value = 0.17).Side eff ects of treatment with ketorolac, were signifcantly less than using morphine sulfate. Temost common adverse eff ects caused by morphine sulfate, were dizziness and vomiting whilenausea and vomiting were the most frequent side eff ects of using ketorolacConclusion : Findings of this study indicated that ketorolac and morphine sulfate were equallyeff ective in relieving the pain of renal colic, but given the severity of side eff ects, ketorolac is thepreferred drug.

Ketorolac Pain Clinics Renal Coli