Impact of body mass index and lipid profiles on blood pressure changes overtime in women with and without a history of preeclampsia: A prospective cohort study

Background and Aim : Preeclampsia (PE), a severe complication in pregnancy, is characterized by newonsethypertension (HTN) [blood pressure (BP) ≥ 140/90 mm Hg] and proteinuria of at least 300 mg in 24-hours after 20 weeks gestation. This disease is considered as one of the most important causes of maternalmortality ratio (MMR) and morbidities, which globally complicates approximately 3-5 % of pregnancies.The aim of this study was to estimate impact of body mass index (BMI) and lipid profiles on blood pressurechanges overtime in women with and without a history of preeclampsia.Methods : This prospective population based study included a total of 3022 eligible women (355 with PEand 2667 non-PE) recruited from participants of the Tehran Lipid and Glucose Study (TLGS) who wereassessed for blood pressure changes and progression to subsequent hypertension over 15-year follow up.Pooled logistic regression model was utilized to estimate odds ratio (OR) of hypertension adjusted for BMIand lipid profiles.Results : The total cumulative incidence rate of hypertension at the median follow-up time ofapproximately 11 years was 34/1000 person-years (95% CI: 28/1000, 41/1000) and person-years 22/1000(95% CI: 20/1000, 24/1000) in PE and non-PE women respectively (p-value < 0.001). Our study showedthat with each kg/m2 of increment in body mass index (BMI), the odds of HTN increases 10%. We alsofound that with each 1 mmol/L increment in triglyceride (TG), the odds of HTN increases approximately18%, whereas with HDL, it decreases to 34%.Conclusion : This study demonstrated that BMI and lipid profiles are important risk factors fordevelopment of HTN.

Keywords:

Blood pressure , hypertension (HTN) , body mass index (BMI) , lipid profiles