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Effect of daily supplementation of cholecalciferol on inflammatory factors and antioxidant status in children with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial.

تعداد صفحات: 1 | تعداد نمایش خلاصه: 68 | نظرات: 0
سال انتشار: 1398
کد COI Paper: NHCHAMED15_037
زبان Paper: Englishglish
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مشخصات نویسندگان Paper Effect of daily supplementation of cholecalciferol on inflammatory factors and antioxidant status in children with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial.

I Namjoo - Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
AM Alavi-Naeini - Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
M Najafi - Department of Psychiatry, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
A Hasanzadeh - Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.

چکیده Paper:

Introduction: ADHD is the most common children s psychiatric disorder with oxidative stress and inflammation condition as playing role in the development of this. The aim of this study was to determine the effect of cholecalciferol (vitamin D3) supplementation on antioxidant activity of superoxide dismutase (SOD) and inflammatory mediators in children with ADHD. Methods: This double-blind clinical trial was performed in 71 children (6-13 years) with ADHD diagnosed by pediatric psychologist and receiving maintenance therapy. Patients were randomly assigned to receive either a single capsule of 1000 IU cholecalciferol (vitamin D3) (n = 36) or placebo (n = 35) daily for 12 weeks. The serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), Homocysteine and the activity of superoxide dismutase (SOD) were determined before and after the intervention. Results: In the intervention group, the mean serum vitamin D and SOD significantly increased significantly after intervention (P<0.001), but the mean serum CRP and IL-6 levels were significantly lower than the intervention before intervention (P<0.001). Independent t-test showed that the average of changes in vitamin D (P<0.001), SOD (P=0.001), IL-6 (P<0.001) and serum CRP (P<0.001) after intervention were significant, but the mean of homocysteine changes in the two groups was not significantly less than the placebo group before the intervention in the intervention group (P=0.46). Conclusion: The present clinical trial study showed that daily supplementation of cholecalciferol can reduce CRP and IL-6 and increase SOD in children with ADHD. The physiological variation in vitamin D may have an important role in ADHD.

کلیدواژه ها:

vitamin D, inflammation, antioxidant, attention deficit hyperactivity disorder, child

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/988217/

کد COI Paper: NHCHAMED15_037

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در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,Effect of daily supplementation of cholecalciferol on inflammatory factors and antioxidant status in children with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial.,پانزدهمین کنگره انجمن علمی تغذیه کودکان ایران,Tehran,,,https://civilica.com/doc/988217

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1398, Namjoo, I؛ AM Alavi-Naeini و M Najafi و A Hasanzadeh)
برای بار دوم به بعد: (1398, Namjoo؛ Alavi-Naeini و Najafi و Hasanzadeh)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

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