Evaluation of Meropenem, Imipenem, Colistin, Teicoplanin and Voriconazole Use in Ayatollah Taleghani Hospital

Abstract: There is a concerning crisis about antibacterial resistance which can be accelerated by the overprescribing of antibiotics. This global Health challenge is associated with severe complications so medical interventions including the use of antimicrobial stewardship programs, activeparticipation of clinical pharmacist in healthcare and antibiotic prescription based on antimicrobial culture should be performed. This study assessed the reasonable use of 5 antimicrobials in Ayatollah Taleghani hospital. Method: Cross-sectional prospective study was conducted in Taleghani Hospital, Tehran, Iran. Totally 121 patients from 3 wards of Intensive Care Unit, General surgery and vascular surgery, with avariety of underlying diseases, entered the study during 3 months of follow up.The information about frequency, duration of treatment, indication and dose of five antimicrobials (Meropenem, Imipenem, Colistin, Teicoplanin, and Voriconazole) were obtained based on the information collected from Hospital Information System, called HIS. Results & discussion: In the Intensive care unit the most prevalent antibiotics were Meropenem, Imipenem (88.73%) and Colistin (11.27%); in vascular surgery unit, Meropenem, Imipenem (96.67%) and Colistin (3.33%) have high rate of administration and finally in general surgery ward Meropenem, Imipenem (88.23%) and Colistin (11.76%) were the most common typeof antibiotics. antibiotic therapy was started for 61.16% patients based on empiric therapy, and microbiological cultures were utilized only for 38.84% of the patients. Antibiograms were used for only 4.95% of patients. Conclusion: According to the collected data, many antibiotics prescriptions were not for therapeutic culture-based reasons. This can be followed by the increasing rate of antibiotic resistance, sothere is a demand for medical training in order to reduce the irrational medical prescription and use. Appropriate use of antibiotics could be promoted by the use of an Antibiotic Stewardship Program (ASP’s). Involving at least one clinical pharmacist or infectious disease pharmacist can play a vital role for this purpose. References: Khan, M. U., et al. (2014). Drug utilization evaluation of meropenem and correlationof side effects with renal status of patients in a teaching based hospital. Pak J Pharm Sci 27(5 Spec no): 1503-1508. foroughinia, f., et al. (2017). Drug utilization evaluation of meropenem: an important broadspectrum antibiotic for the treatment of serious bacterial infections in hospitalized patients. Trends in Pharmaceutical Sciences 3(1): 25-30. Salehifar, E., et al. (2015). Drug use evaluation of Meropenem at atertiary care university hospital: A report from Northern Iran.

Keywords:

Antibiotic Stewardship Program , Antibacterial agents , Drug Resistance , Meropenem , Colistin