Effect of calcitriol supplementation on infectious biomarkers including propcalcitonin (PCT) and presepsin in patients with positive systemic inflammatory response

Background: sepsis is one of the common cases of hospitalization of patients in the intensive care unit. A significant role for vitamin D in sepsis has been proposed, which is due to the important effect of its active metabolite, calcitriol, on the host defense system. In the presentstudy, the effect of calcitriol on the markers of infection, including PCT and presepsin, has been studied in these patients. Study design: This study was designed as a randomized, open label clinical trial. Patients were divided into intervention and control groups. Patients in interventiongroup received intravenous calcitriol daily for 3 days. The serum levels of PCT and presepsin were evaluated on days 0, 3 and 5 after injection Results: A total of 27 patients with positive systemic inflammatory response were included and randomly divided into 2 groups (14 patients in theintervention group and 13 patients in the control group). In terms of basal factors, changes in SOFA score and blood levels of vitamin D were not significantly different between the control and intervention groups. Procalcitonin levels on day 5 and the differences between day 5 and 0 weresignificantly different between intervention and control group (P = 0.02 and P = 0.026). Perspepsin on the 3rd and 5th days in the intervention group was decreased, but in the control group there was a increasing trend, but there was no significant difference between the two groups at days 3 and 5, and the difference between the 3rd and the 5th day with the presepsin at the time of entering the study. Conclusion: Finally, the results of this study showed that administration of intravenous calcitriol can reduce the level of procalcitonin as a diagnostic marker for sepsis but did not have asignificant effect on presepsin.

Keywords:

sepsis , SIRS , calcitriol , PCT , Presepsin