Developmental and Epileptic Encephalopathies of Infancy

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

EPILEPSEMED16_020

تاریخ نمایه سازی: 28 بهمن 1398

Abstract:

Developmental and Epileptic encephalopathies(DEE), define as syndromes in which epileptic seizures and epileptiform activity contribute to or exacerbate underlying brain dysfunction, leading to prominent developmental delay. Developmental impairment originates from a direct consequence of the genetic mutation, in addition to the effect of the frequent epileptic activity on brain development. These mutated genes are commonly responsible for both epilepsy and deviation from developmental milestones. Despite choosing the most appropriate antiepileptic drugs for the seizure type and syndrome, the results are often disappointing, and polytherapy and/or alternative therapy becomes unavoidable. In this lecture, I will discuss the clinical and electroencephalographic characteristics and evolution and management of age-related early epileptic encephalopathies, recognized by the International League Against Epilepsy, as follows: early infantile epileptic encephalopathy (Ohtahara syndrome), early myoclonic encephalopathy, epilepsy of infancy with migrating focal seizures, various early epileptic encephalopathy syndromes, infantile spasms(West syndrome), severe myoclonic epilepsy in infancy (Dravet syndrome) and myoclonic-atonic epilepsy (Doose syndrome). Precision medicine plays an important role in future management of these epileptic syndromes.

Authors

Reza Shervin Badv

Pediatric Neurologist and epileptologist; Tehran Children’s Medical Cener, Pediatrics center of excellence. Tehran University of medical Sciences.