The Relationship Between Selenium and Glutathione Peroxidase in Patients with Epilepsy in West Azarbaijan Province

Epileptic seizures are a common manifestation of mitochondrial dysfunction in mitochondrial encephalopathies. Selenium is one of the strong antioxidants in the body that interferes with and damages the cell s adverse reactions. Glutathione is also the most abundant intracellular non-enzymatic defense against oxidizing agents in the living organism, especially its brain tissue, and glutathione peroxidase is one of the most important enzymes in the pathway of glutathione metabolism. The purpose of this study was to investigate the association between selenium and glutathione peroxidase in epileptic patients. Be it. Materials and Method: Our statistical population included 100 infants with epilepsy in West Azarbaijan province in year 1 and 2 healthy children as control group. Demographic information including age, time of onset of disease, history of seizure, family history and medication use as Questionnaires were completed in both groups. Blood samples were obtained from all subjects. Blood samples were collected in tubes containing KEDTA for selenium and heparin for anticoagulation to measure glutathione peroxidase. It was measured by atomic absorption through hydrated ions and not at Data were analyzed with SPSS V.24 software quality. Results: The mean age of the study group was 9.3 12 12 years, of which 3% were boys and 5% were girls.The mean selenium level in healthy subjects was 91.2 ng and 60.17 ng in healthy subjects, respectively. The most common type of seizure in generalized tonic clonic patients was 41.7% and the lowest type was atonic 6.2%. Imaging results were 21.7% in cerebral atrophy and 4.7% in structural disorders and 37.9% in normal subjects. 72% of patients had lower serum selenium levels than the control group. Glutathione peroxidase was 85% in the control group and 74% in the control group. The only significant family history and maternal age in pregnancy were related to demographic parameters. (P = 0.005 OR = 3 / 42-9 / 88 OR = 95%) Conclusion: Based on the results, the level of glutathione peroxidase and selenium in patients with epilepsy is lower than normal, which can be used as one of the previously identified diagnostic factors.

Keywords:

glutathione peroxidase , selenium , epilepsy