A green approach to electrosynthesis of chromeno[3’,4’:5,6] pyrano [2,3-d] pyrimidines by electrochemistry

Eletrochemistry is a broad, useful, and selective technique method in many research fields. Among them, the investigation of performance of electrochemical methods indetermination, synthesis and selective reduction/oxidation of different elements and molecules have attracted growing attention due their intrinsic advantages such asselectivity, low cost, and high yield of synthesis. Moreover, electrocatalytic synthesis of organic molecules is known as a green and environmentally benign method. Inthe present form, electrocatalytic multicomponent transformation of barbituric acid, aromatic aldehydes, and 4-hydroxycumarin was carried out. The electrocatalytic transformation was done in alcohols in the presence of tetrabutylammounium flouride as an electrolyte in an undivided cell containing an iron electrode as the cathode and aPt electrode as the anode at a constant current leads to substituted chromeno[3’,4’:5,6]pyrano[2,3-d] pyrimidines in good to high yields (54-92%) at room temperature.The yield of reaction was obtained by gravimetric analysis and calculated upon theoretical conversion. The application of the effective electrocatalytic cascade method to the formation of chromeno-pyrano-pyrimidines is also beneficial from the viewpoint of diversity-oriented large-scale processes and represents an example of facile environmentally benign synthetic concept for electrocatalytic multicomponent reactions. The products were characterized with proper analytical methods such as elemental analysis (CHN), FT-IR, 1H-NMR, and 13C-NMR spectrometry. Finally, the obtained results showed that the desired products were synthesized

Keywords:

Analytical methods , Characterization , Electrocatalytic transformation , Chromene , Multicomponent reaction , Pyranopyrimidine