Neurological Disorders due to Recurrent Hypoglycemia

The most important material for the brain tissues is glucose .The brain utilizes around (25%) of the body s glucose, and it s metabolism thought to be primarily by astrocytes through non-insulin dependent (GLUT-1) transporter and insulin dependent (GLUT-4) transporter, but the brain contains very limited stores of glycogen, and therefore it can t regulate it s function for long time without glucose.So neuronal damage can lead to multiple neurological manifestations as a result of hypoglycemia acutely; stroke like symptoms, movement disorders (tremor, ataxia, difficulty of walking), seizures, coma and death; chronically and repetitive leads to cognitive impairment. Which means clinical picture appears according to the area of neuronal damage.

Keywords:

NMDA receptor: N-Methyl-D-Aspartate receptor , WM: White Matter , ischemia , neuronal DNA , Hypoxia , Basal ganglia , cerebral peduncle