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Title

Role of Stem Cell Elements in Chronic Myeloid Leukemia

Role of Stem Cell Elements in Chronic Myeloid Leukemia
Year: 1393
COI: JR_RIJO-3-1_008
Language: EnglishView: 159
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Authors

Ehsan Ghayoor Karimiani - Molecular Diagnostic Unit, Research and Education Department, Razavi Hospital, Mashhad, IR Iran
Abolghasem Allahyari - Hematology Oncology Department, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran

Abstract:

Context: Chronic myeloid leukemia (CML) is believed to occur following the clonal expansion of haematopoietic stem cells and ismaintained by expanding clones which have acquired a BCR-ABL fusion gene. The properties of untreated CML stem/progenitor cellscorrelate with a subsequent response to chemotherapy. Evidence Acquisition: The fifty two significant articles discussing the stem cell in chronic myeloid leukemia from 1996 to 2012 wereselected according to the authors’ experience. Results: Studies have shown that primitive CML cells are less responsive to Tyrosine Kinase Inhibitors (TKIs) and are a reservoir for therelapse of multi drug resistant (MDR). Conclusions: Following that, minimal residual disease (MRD) measurement aims to detect very small numbers of leukemic cells, belowthe detection limit of morphology and cytogenetics with molecular techniques for patients in clinical remission.

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This Paper COI Code is JR_RIJO-3-1_008. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/994452/

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Ghayoor Karimiani, Ehsan and Allahyari, Abolghasem,1393,Role of Stem Cell Elements in Chronic Myeloid Leukemia,https://civilica.com/doc/994452

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