Serum Pro-Oxidant-Antioxidant Balance, Advanced Oxidized Protein Products (AOPP) and Protein Carbonyl in Patients With Stroke

Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_RIJO-4-2_008

تاریخ نمایه سازی: 6 اسفند 1398

Abstract:

Background: Stroke is the second cause of death and disability in the world, and oxidative stress which could be considered asa prognostic factor in patients for prevention, follow up and determination of stroke’s severity has a conceivable role in neuraldamage.Objectives: The aim of our study was to explain the association between oxidant/antioxidant imbalance as a prognostic factor inpatients with stroke.Patients and Methods: Pro-oxidant-antioxidant balance (PAB), advanced oxidized protein products (AOPP) and protein carbonylwere measured in patients with ischemic stroke and hemorrhagic stroke as well as healthy group. Sera were collected from 18 ischemicand 23 hemorrhagic stroke patients, and 34 healthy volunteers. The PAB assay, routine biochemical parameters, lipid profileand total protein concentration were assessed in patients and healthy group.Results: The level of AOPP (P < 0.007), protein carbonyl (P < 0.001) and PAB (P < 0.01) were significantly higher in stroke patientsthan the healthy group.Conclusions: There are increased level of protein carbonyl, AOPP and PAB in patients with stroke. Measuring these factors maybe beneficial as prognostic factors in treatment and follow up of the patients with both hemorrhagic and ischemic strokes. Moreinvestigations with more cases and longer follow up are needed to approve that these factors play an important role in prognosisof stroke.

Authors

Vajiheh Toloue Pouya

Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran

Seyed Issac Hashemy

Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran

Ali Shoeibi

Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran

Abolfazl Nosrati Tirkani

Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran

Shima Vavallaie

Biochemistry of Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran

Farnaz Zahedi Avval

Department of Biochemistry, Biochemistry and Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran