Jaleh Yousefi - Department of Otolaryngology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Asghar Akhavan - Department of Otolaryngology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Reza Hoseini-Motlagh - Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Shahin Banaei-Boroujeni - Department of Otolaryngology, Resident of Otolaryngology, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Yunes Panahi - Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Mohammad Hossein Khosravi - Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran- International Otorhinolaryngology Research Association (IORA), Universal Scientific Education and Research Network (USERN), Tehran, IR Iran

Background: Chronic rhinosinusitis (CRS) is the inflammation of paranasal sinus mucous membranes. Considering the influenceof fungi on chronic rhinosinusitis and different results concerning the effect of Amphotericin B on improvement of this condition;this study aimed to determine the effect of topical Amphotericin B on improvement of the symptoms in patients with CRS.Methods: In this double-blind randomized clinical trial, 80 patients with chronic rhinosinusitis who visited the allergy clinic ofBaqiyatallah Hospital from June to October 2014 were randomly allocated to two groups; the first group received 10 cc topical lavageof Amphotericin B (5 cc each nostril for every 12 hours) and the second group received placebo for three months. Symptoms, nasalmucusa smear, serum level of inflammatory cytokines, CT scan and rhinoscopy score changes were evaluated in both groups afterthree months.Results: Fifty-five male and 25 female patients were evaluated in two groups. The mean age was 26.1 2.36 and 27.9 1.59 yearsin intervention and control groups respectively (P = 0.08). There were no significant differences in demographic data between thegroups (P > 0.05). Nasal obstruction, post nasal drip (PND), reduced sense of smell, quality of life, CT scan and rhinoscopy scoreswere not significantly different between the two groups after intervention (P > 0.05). Facial pain severity score was significantlymore reduced in intervention group in comparison with control group (P < 0.01).Conclusions: We concluded that application of Amphotericin B as an adjunctive medication to other common treatments, doesnot seem to be an efficient method for improvement of CRS symptoms.

Quality of Life, Symptoms, Chronic Rhinosinusitis, Amphotericin B, VAS Score