Effect of Lidocaine Infusion during General Anesthesia on Neutrophil-Lymphocyte-Ratio in Breast Cancer Patients Candidate for Mastectomy; a Clinical Trial

Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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JR_SBMU-1-4_006

تاریخ نمایه سازی: 6 اسفند 1398

Abstract:

Background: Considering the anti-inflammatory role of intravenous (IV)lidocaine, its analgesic properties, and its ability to reduce the need foropioids during and after surgery, in this study we decided to evaluate theeffect of IV lidocaine infusion on levels of inflammatory factors based onneutrophil to lymphocyte ratio (NLR) in breast cancer surgery candidates.Materials and Methods: The present study is a randomized clinical trial.All the patients with ASA: I, II breast cancer, who were candidates ofmastectomy elective surgery were included. The patients were allocated to 2groups of IV lidocaine and normal saline based on a random numbers table.After inducing anesthesia similar for all the patients, using 0.02 mg/kgmidazolam, 2-4 μg/kg fentanyl, 1-2 mg/kg propofol and 0.5 mg/kgatracurium, either 1.5 mg/kg/hr IV lidocaine or the same volume of normalsaline was infused intravenously. Glasgow prognostic score and NLR werecalculated before and 6, 24, and 48 hours and 14 days after surgery.Results: A total of 63 women suffering from breast cancer, with themean age of 49.25±9.32 years, were included and allocated tolidocaine and control groups using simple randomization. Therewas no significant difference between the 2 groups regarding meanage (p=0.591), incision size (p=1.000), and duration of surgery(p=0.752). Using mixture model regression analysis and afteradjusting the effect of baseline variables, a significant differencewas detected between the groups regarding NLR during the followupperiod (p=0.006)Conclusion: Based on the findings of the present study, it seems that NLRchanges were smaller in breast cancer patients, who had received a lidocaineinfusion during surgery, compared to the control group.

Authors

Elham Memary

Department of Anesthesiology, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Alireza Mirkheshti

Department of Anesthesiology, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mahshid Ghasemi

Department of Anesthesiology, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mehrdad Taheri

Department of Anesthesiology, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Ali Arhami Dolatabadi

Department of Anesthesiology, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Atiye Kaboudvand

Department of Anesthesiology, Imam Hosein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran