Mahdi Mahdavi - School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mahdi Taherian - Food and Drug Research Institute, Iran Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran
Hossein Maghsoudi - Biotechnology Research Center, Payamenoor University, Tehran, Iran
Reza Taherian - Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Osteoarthritis (OA) is a rheumatological disorder accompanied with imbalance between anabolic and catabolic mediators that lead to the destruction of homeostasis of articular cartilage. Currently, Steroids and non-steroidal anti-inflammatory drugs are commonly used in the management of OA. Besides the various side effects of these drugs, they can just moderately alleviate symptoms of OA. Hence, to achieve safe and efficacious drugs, the research tendency toward exploration of novel sources has been grown up. Various previous researches have focused on the use of medicinal plants in the treatment of OA. This review focuses on the most efficacious medicinal plants and drugs considering related laboratory and clinical evidences. More investigations are needed to develop therapeutic agents with disease-modifying properties to treat OA.

Osteoarthritis; Pain; Medicinal Plants; Inflammation