Giardia Outbreak in Duodenal Biopsy Celiac Cases

Objectives : Giardiasis is a diarrheal disease caused by Giardia lambelia. Celiac disease is an autoimmune sensitization to gluten associated with malabsorption.The purpose ofthe current study was to determine the prevalence of giardiasis in duodenal biopsies of celiac and non-celiac patients with dyspepsia. Materials& Methods : It is a descriptive-analytic study on 500 duodenal biopsies of dyspeptic patients referred to Ali ebn Abi Talib hospital of Zahedan in 2015- 2016.Celiac and non-celiac patients biopsies according to previous pathological diagnosis classified. Presence of giardiasis in biopsies was studied. Statistical analysis of the data was done by SPSS software. The data statistically analyzed using Chi-square test, 95%confidence interval, percentage, mean and standard deviation. (P-value < 0.05). Results& Discussion: In 500 duodenal biopsies, 8 cases had giardiasis (6/1%), 35 cases had celiac disease (7%), 465 cases didn t have celiac disease (93%). In celiac cases there was no giardiasis, 8 giardiasis(7/1%) was observed in non-celiac cases. 274 cases was male(54.8%) and 226 cases(45.2%) was female. 19 cases(54.3%) of male cases and 16 cases(45.7%) of female cases diagnosed to have celiac disease. In non-celiac cases, 3 males (1.2%) and 5 females (2.4%) was diagnosed giardiasis. The results indicated that giardiasis didn t have a significant role in dyspepsia and celiac disease however giardiasis had a more significant role in dyspepsia. It is better that duodenal biopsy be taken while endoscopy performs to prevent the development of duodenal abnormalities like giardiasis and celiac complications.

Keywords:

Giardiasis , prevalence , celiac