Potential Reno protective Effects of coenzyme Q10 on gentamicin toxicity in rat. Original article

Background and Objective: The main side effect of Aminoglycosides is nephrotoxicity. Gentamicin GM is one the Aminoglycoside antibiotics which is routinely used to treat infections gram-negative .The antioxidant, anti-inflammatory and vasodilatory effects of coenzyme Q10 was investigated on gentamicin nephrotoxicity in rats.Materials and Methods: Renal injury induced by i.p.injection of gentamicin 100 mg/kg for 8 consecutive days. Coenzyme Q10 10 mg/kg/day, i.p treatment was done for 8 consecutive days as co-treatment and post-treatment protocol. Left kidney, for doing histological experiments in 10% buffered formaldehyde and right kidney for biochemical experiments in fluid nitrogen was preserved. Results: Co-treatment with Coenzyme Q10 significantly decreased MDA levels 2.13 ±0.24μmol/ gkw; p<0.001 , and significantly increased FRAP levels 24.44±0.42mmol/gkw; p<0.001 . Post-treatment with coenzyme Q10 significantly decreased MDA levels 3.08 ±0.12μmol/ gkw; p<0.001 and significantly increased and FRAP levels 24.34±0.75mmol/gkw; p<0.001 that is reduced by gentamicin.Conclusion: According to the results, this study showed that post- treatment with coenzyme Q10 more protective effect on the kidney tissue and increased antioxidant and anti-inflammatory defense.

Keywords:

Nephrotoxicity , Gentamicin , coenzyme Q10 , antioxidant.