Saber Jafari-Maskouni - MSc Student, Department of Nutrition, Faculty of Medical Sciences, Zahedan University of Medical Sciences, Zahedan, Iran
Somayeh Asghari - Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Zahedan University of Medical Sciences, zahedan, Iran
Mansour Shahraki - ۳Ph.D, Assotiate Professor, Department of Nutrition, Faculty of Medical Sciences, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan
Mahmoud Ali Kaykhaei - PhD, Assotiate Professor, Department of Internal Medicine, Faculty of Medical Sciences, Zahedan University of Medical Sciences, Zahedan, Iran
Alireza Dashipour - PhD, Assotiate Professor, Department of Food Sciences and Nutrition, Faculty of Medical Sciences, Zahedan University of Medical Sciences, Zahedan, Iran

Introduction: Overweight and obesity are the most common risk factors for type 2 diabetes mellitus. Our aim was to investigate the effects of bunium persicum (BP) on Waist circumference (WC), body mass index (BMI) and Nesfatin-1 among overweight or obese T2DM patients.Methods: The place of participant recruitment was the diabetic clinic of Bo’Ali hospital in Zahedan. Based on the eligibility criteria, 60 participants were randomly divided into two groups as BP (n=30) or placebo (n=30). The supplementation was one 1000 mg capsules 2 times/day with launch and dinner for 3 months. Weight, height and waist circumference (WC) were measured. Body mass index (BMI) was also calculated.Results: In comparison with placebo, PB significantly decreased WC and BMI (P<0.05). After adjustment for confounders, the changes were similar (P<0.05). The differences in Nesfatin-1 were not significant (P> 0.05).Conclusion: PB supplement improved body BMI and WC among overweight or obese T2DM patients; though, further trials are suggested to confirm results.Trial Registration: Iranian Registry of Clinical Trials (IRCT) number IRCT20181207041876N1, 18/01/2019.

Bunium persicum, Overweight, Obesity, Waist circumference, Body mass index, Nesfatin-1