Evalution of antigenicity for cagA antigenic fragments recombinant protein of Helicobacter pylori

The gram negative, microaerophilic bacterium Helicobacter pylori colonizes the human gastric mucosa and causes atrophic gastritis, peptic ulcer, and gastric carcinoma. The cytotoxin-associated gen A (CagA) is one of the most important virulence factors in H.pylori. The aim of the present study was to construct a recombinant protein containing antigenic regions of cagA and determining its antigenicity as a vaccine candidate of H. pylori

Keywords:

Helicobacter pylori , cagA gene , antigenicity , antigenic regions