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MicroRNA expression profiling in sulfur mustard exposed patients: biological significance and diagnostic utility.

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Year: 2014
COI code: CIGS13_0725
Paper Language: English

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Authors MicroRNA expression profiling in sulfur mustard exposed patients: biological significance and diagnostic utility.

  Sedigheh Gharbi - Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Shahriar Khateri - Janbazan Medical and Engineering Research Center (JMERC), Tehran, Iran
Mohammad Reza Soroush - Janbazan Medical and Engineering Research Center (JMERC), Tehran, Iran
  Fatemeh Mirzadeh - Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Abstract:

Sulfur mustard (SM) is an active vesicating agent which was used against both military and civilian population of Iran during the Iran-Iraq war (1980-1988). Due to its unclear mechanism of action in pathogenesis of lung, clinical management strategies, especially diagnostic protocols and treatment are not well defined. microRNAs are promising biomarkers that could significantly discriminate different pathological and biological states among diseases and organs failure. MoreovermicroRNAs could be stably detected in bio-fluids like serum that grantee them as non-invasive biomarkers. We profiled739 microRNAs in serum samples of 43 SM exposed patients and 27 matched healthy volunteers. Expression patterns offive highly altered microRNAs including mir-663, miR-148a and miR-143-3p were further validated by real-time qPCR. microRNA profile analysis identified statistical unique microRNA panel, which could significantly distinguish patients with three pathological states: mild, moderate and severe. This panel was also applicable on SM exposed veterans who had no clinically recorded symptoms. Bioinformatic analysis along with functional investigations showed that altered microRNAs were related to cell cycle arrest and senescence pathways which are in concordance to pathological manifests of patients. Our presented microRNAs panel could be used diagnostically with high accuracy for classifying SM exposed patients and also for choosing treatments strategies based on molecular status of the disease

Keywords:

microRNA profiling – sulfur mustard – senescence – cell cycle arrest

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COI code: CIGS13_0725

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Gharbi, Sedigheh; Shahriar Khateri; Mohammad Reza Soroush & Fatemeh Mirzadeh, 2014, MicroRNA expression profiling in sulfur mustard exposed patients: biological significance and diagnostic utility., 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_0725.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Gharbi, Sedigheh; Shahriar Khateri; Mohammad Reza Soroush & Fatemeh Mirzadeh, 2014)
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Type: state university
Paper No.: 25939
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