Published in: 12th Congress of Iranian Genetics Society
COI code: CIGS13_0725
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors MicroRNA expression profiling in sulfur mustard exposed patients: biological significance and diagnostic utility.Sedigheh Gharbi - Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Shahriar Khateri - Janbazan Medical and Engineering Research Center (JMERC), Tehran, Iran
Mohammad Reza Soroush - Janbazan Medical and Engineering Research Center (JMERC), Tehran, Iran
Fatemeh Mirzadeh - Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Abstract:Sulfur mustard (SM) is an active vesicating agent which was used against both military and civilian population of Iran during the Iran-Iraq war (1980-1988). Due to its unclear mechanism of action in pathogenesis of lung, clinical management strategies, especially diagnostic protocols and treatment are not well defined. microRNAs are promising biomarkers that could significantly discriminate different pathological and biological states among diseases and organs failure. MoreovermicroRNAs could be stably detected in bio-fluids like serum that grantee them as non-invasive biomarkers. We profiled739 microRNAs in serum samples of 43 SM exposed patients and 27 matched healthy volunteers. Expression patterns offive highly altered microRNAs including mir-663, miR-148a and miR-143-3p were further validated by real-time qPCR. microRNA profile analysis identified statistical unique microRNA panel, which could significantly distinguish patients with three pathological states: mild, moderate and severe. This panel was also applicable on SM exposed veterans who had no clinically recorded symptoms. Bioinformatic analysis along with functional investigations showed that altered microRNAs were related to cell cycle arrest and senescence pathways which are in concordance to pathological manifests of patients. Our presented microRNAs panel could be used diagnostically with high accuracy for classifying SM exposed patients and also for choosing treatments strategies based on molecular status of the disease
Keywords:microRNA profiling – sulfur mustard – senescence – cell cycle arrest
COI code: CIGS13_0725
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Gharbi, Sedigheh; Shahriar Khateri; Mohammad Reza Soroush & Fatemeh Mirzadeh, 2014, MicroRNA expression profiling in sulfur mustard exposed patients: biological significance and diagnostic utility., 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_0725.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Gharbi, Sedigheh; Shahriar Khateri; Mohammad Reza Soroush & Fatemeh Mirzadeh, 2014)
Second and more: (Gharbi; Khateri; Soroush & Mirzadeh, 2014)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: state university
Paper No.: 25939
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
New Related Papers
- Composition, distribution and economic importance of insect pests of prioritized aromatic plants in some growing of Ethiopia
- Quantitative genetic analysis of Dromedary camel (Camelus dromedaris) under pastoral management in central desert of Iran
- Bimolecular identification of M.ovinpeumoniae from nasal swab samples of sheep from various districts of Balochistan, Pakistan
- Salt and water stress of ACCase herbicides resistant and susceptible populations of rigid ryegrass (Lolium rigidum)
- A Monte Carlo study on Photoneutron Spectrum around Elekta SL75/25 18 MV linear accelerator
The Above articles are recently indexed in the related subjects
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.