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Association of TLR4 gene polymorphisms (Asp299Gly, Thr399Ile) and the severity of clinical symptoms of Familial Mediterranean fever in population of north-west of Iran

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Year: 2014
COI code: CIGS13_0926
Paper Language: English

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Authors Association of TLR4 gene polymorphisms (Asp299Gly, Thr399Ile) and the severity of clinical symptoms of Familial Mediterranean fever in population of north-west of Iran

  Negar Laghaeian - Ahar Branch of Islamic Azad University, Department of Biology, Molecular Genetics M.Sc.
  Mortaza Jabbarpour Bonyadi - Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz

Abstract:

Familial Mediterranean Fever (FMF) is an autosomal recessive auto-inflammatory disorder which is caused by mutations of the responsible gene (MEFV). The disease characterized by recurrent self-limited attacks of fever with peritonitis, pleuritis, arthritis, myalgia, erysipelas-like skin lesions and amyloidosis. Toll-like receptors (TLRs) are involved in the activation ofan innate immune system. TLR-4(Asp299Gly and Thre399Ile) polymorphisms down-regulate inflammation. Weinvestigated the effect of these polymorphisms on the development or resistance of clinical symptoms severity in FMFpatients. In this study we investigated 86 FMF patients contain two groups (with and without) of clinical symptoms. TLR-4(Asp299Gly and Thr399Ile) polymorphisms were analyzed with the polymerase chain reaction restriction fragment length polymorphism method (PCR-RFLP). A significant association between two groups of patients with/without some clinical symptoms like fever, Peritonitis, Myalgia and Eriseplemya were observed (P value ˂ 0.05). Previous studies in the otherpopulations suggest the association between TLR-4(Asp299Gly and Thr399Ile) polymorphisms and severity of FMF; alsoour data showed an association between these polymorphisms and severity of some clinical symptoms of FMF patients in north-west of Iran and demonstrated the role of A and C alleles in the severity of inflammation in FMF patients with M694V homozygous mutation in this cohort

Keywords:

Familial Mediterranean fever, MEFV, TLR4

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COI code: CIGS13_0926

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Laghaeian, Negar & Mortaza Jabbarpour Bonyadi, 2014, Association of TLR4 gene polymorphisms (Asp299Gly, Thr399Ile) and the severity of clinical symptoms of Familial Mediterranean fever in population of north-west of Iran, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_0926.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Laghaeian, Negar & Mortaza Jabbarpour Bonyadi, 2014)
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Type: Azad University
Paper No.: 2252
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